Vancomycin determination by disrupting electron-transfer in a fluorescence turn-on squaraine – anthraquinone triad

• Main Authors: Ng, Shue Mei, Wu, Xiangyang, Muhammad Faisal Khyasudeen, Nowakowski, Paweł J., Tan, Howe-Siang, Xing, Bengang, Yeow, Edwin Kok Lee
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Vancomycin; Electron Transfer
• Online Access: https://hdl.handle.net/10356/139278
• Institution: Nanyang Technological University

A highly sensitive and selective probe for Vancomycin (Van) in aqueous and serum samples is developed in this study. The probe is based on a triad consisting of a near-infrared squaraine dye (Seta-640) conjugated to two anthraquinone molecules via Lys-d-Ala-d-Ala peptides. In the absence of Van, the...