Palladium-catalyzed asymmetric allylic alkylations of colby pro-enolates with MBH carbonates : enantioselective access to quaternary C-F oxindoles

• Main Authors: Zhu, Yi, Mao, Yu, Mei, Haibo, Pan, Yi, Han, Jianlin, Soloshonok, Vadim A., Hayashi, Tamio
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Allylic Alkylations; Enantioselectivity
• Online Access: https://hdl.handle.net/10356/139358
• Institution: Nanyang Technological University

Owing to the innovative applications of fluorinated compounds in many areas of technology and medicine, methods for the preparation of C-F quaternary fluorine containing compounds are in extremely high demand. Here, we report the discovery of a general procedure for an SN 2 reaction catalyzed by Pd/...