The effect of temporal manipulation of transforming growth factor beta 3 and fibroblast growth factor 2 on the derivation of proliferative chondrocytes from mensenchymal stem cells - a study monitored by quantitative reverse transcription polymerase chain reaction and molecular beacon based nanosensors

• Main Authors: Tay, Li Min, Wiraja, Christian, Wu, Yingnan, Yang, Zheng, Lee, Eng Hin, Xu, Chenjie
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Bioengineering; Epiphyseal Growth Plate; Physis
• Online Access: https://hdl.handle.net/10356/139528
• Institution: Nanyang Technological University

Proliferative chondrocytes are critical to realize regeneration of damaged epiphyseal growth plate. However, acquiring autologous replacement cells involves highly invasive procedures and often results in limited cell quantity. Mesenchymal stem cells (MSCs) are a potential source of chondrogenic cel...