Polyamine regulator AMD1 promotes cell migration in epidermal wound healing

• Main Authors: Lim, Hui Kheng, Anisa Rahim, Leo, Vonny Ivon, Das, Shatarupa, Lim, Thiam Chye, Uemura, Takeshi, Igarashi, Kazuei, Common, John, Vardy, Leah Anne
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; AMD1; Cell Migration
• Online Access: https://hdl.handle.net/10356/139584
• Institution: Nanyang Technological University

Wound healing is a dynamic process involving gene-expression changes that drive re-epithelialization. Here, we describe an essential role for polyamine regulator AMD1 in driving cell migration at the wound edge. The polyamines, putrescine, spermidine, and spermine are small cationic molecules that p...