Autophagy as a cellular stress response mechanism in the nervous system

Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is o...

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Main Authors: Peker, Nesibe, Gozuacik, Devrim
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/139716
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1397162020-05-21T04:43:18Z Autophagy as a cellular stress response mechanism in the nervous system Peker, Nesibe Gozuacik, Devrim School of Biological Sciences Science::Biological sciences Autophagy Cellular Stress Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is one of the mechanisms that supports cell survival under stressful conditions. Autophagic vesicle engulfs the cargo and transports it to lysosome for degradation and turnover. As such, autophagy eliminates abnormal proteins, clears damaged organelles, limits oxidative stress and helps to improve metabolic balance. Nervous system cells and particularly postmitotic neurons are highly sensitive to a spectrum of insults, and autophagy emerges as one of the key stress response mechanism, ensuring health and survival of these vulnerable cell types. In this review, we will overview mechanisms through which cells cope with stress, and how these stress responses regulate autophagy, with a special focus on the nervous system. 2020-05-21T04:43:18Z 2020-05-21T04:43:18Z 2020 Journal Article Peker, N., & Gozuacik, D. (2020).Autophagy as a cellular stress response mechanism in the nervous system. Journal of molecular biology, 432(8), 2560-2588. doi:10.1016/j.jmb.2020.01.017 0022-2836 https://hdl.handle.net/10356/139716 10.1016/j.jmb.2020.01.017 31962122 2-s2.0-85078832016 8 432 2560 2588 en Journal of molecular biology © 2020 Elsevier Ltd. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Biological sciences
Autophagy
Cellular Stress
spellingShingle Science::Biological sciences
Autophagy
Cellular Stress
Peker, Nesibe
Gozuacik, Devrim
Autophagy as a cellular stress response mechanism in the nervous system
description Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is one of the mechanisms that supports cell survival under stressful conditions. Autophagic vesicle engulfs the cargo and transports it to lysosome for degradation and turnover. As such, autophagy eliminates abnormal proteins, clears damaged organelles, limits oxidative stress and helps to improve metabolic balance. Nervous system cells and particularly postmitotic neurons are highly sensitive to a spectrum of insults, and autophagy emerges as one of the key stress response mechanism, ensuring health and survival of these vulnerable cell types. In this review, we will overview mechanisms through which cells cope with stress, and how these stress responses regulate autophagy, with a special focus on the nervous system.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Peker, Nesibe
Gozuacik, Devrim
format Article
author Peker, Nesibe
Gozuacik, Devrim
author_sort Peker, Nesibe
title Autophagy as a cellular stress response mechanism in the nervous system
title_short Autophagy as a cellular stress response mechanism in the nervous system
title_full Autophagy as a cellular stress response mechanism in the nervous system
title_fullStr Autophagy as a cellular stress response mechanism in the nervous system
title_full_unstemmed Autophagy as a cellular stress response mechanism in the nervous system
title_sort autophagy as a cellular stress response mechanism in the nervous system
publishDate 2020
url https://hdl.handle.net/10356/139716
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