Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor

We report a smartphone label-free biosensor platform based on grating-coupled surface plasmon resonance (GC-SPR). The sensor system relies on the smartphone's built-in flash light source and camera, a disposable sensor chip with Au diffraction grating and a compact disk (CD) as the spectra disp...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhang, Jinling, Khan, Imran, Zhang, Qingwen, Liu, Xiaohu, Dostalek, Jakub, Liedberg, Bo, Wang, Yi
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Online Access:https://hdl.handle.net/10356/139808
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-139808
record_format dspace
spelling sg-ntu-dr.10356-1398082020-06-01T10:13:51Z Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor Zhang, Jinling Khan, Imran Zhang, Qingwen Liu, Xiaohu Dostalek, Jakub Liedberg, Bo Wang, Yi School of Materials Science & Engineering Centre for Biomimetic Sensor Science Engineering::Materials Surface Plasmon Resonance Biosensor We report a smartphone label-free biosensor platform based on grating-coupled surface plasmon resonance (GC-SPR). The sensor system relies on the smartphone's built-in flash light source and camera, a disposable sensor chip with Au diffraction grating and a compact disk (CD) as the spectra dispersive unit. The Au grating sensor chip was modified with a synthetic peptide receptor and employed on the GC-SPR detection of lipopolysaccharides (known as endotoxins) with detection limit of 32.5ng/mL in water. Upon incubation of various small and macro-molecules with the synthetic peptide modified sensor chips, we concluded the good selectivity of the sensor for LPS detection. In addition, the sensor shows feasibility for the detection of LPS in commonly used clinical injectable fluids, such as clinical-grade 0.9% sodium chloride intravenous infusion, compound sodium lactate intravenous infusion and insulin aspart. The developed sensor platform offers the advantage of portability and simplicity, which is attractive for point-of-care and remote detection of biomedical and environmental targets. ASTAR (Agency for Sci., Tech. and Research, S’pore) 2020-05-21T09:21:29Z 2020-05-21T09:21:29Z 2017 Journal Article Zhang, J., Khan, I., Zhang, Q., Liu, X., Dostalek, J., Liedberg, B., & Wang, Y. (2018). Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor. Biosensors and Bioelectronics, 99, 312-317. doi:10.1016/j.bios.2017.07.048 0956-5663 https://hdl.handle.net/10356/139808 10.1016/j.bios.2017.07.048 28787676 2-s2.0-85026783350 99 312 317 en Biosensors and Bioelectronics © 2017 Elsevier B.V. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Engineering::Materials
Surface Plasmon Resonance
Biosensor
spellingShingle Engineering::Materials
Surface Plasmon Resonance
Biosensor
Zhang, Jinling
Khan, Imran
Zhang, Qingwen
Liu, Xiaohu
Dostalek, Jakub
Liedberg, Bo
Wang, Yi
Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
description We report a smartphone label-free biosensor platform based on grating-coupled surface plasmon resonance (GC-SPR). The sensor system relies on the smartphone's built-in flash light source and camera, a disposable sensor chip with Au diffraction grating and a compact disk (CD) as the spectra dispersive unit. The Au grating sensor chip was modified with a synthetic peptide receptor and employed on the GC-SPR detection of lipopolysaccharides (known as endotoxins) with detection limit of 32.5ng/mL in water. Upon incubation of various small and macro-molecules with the synthetic peptide modified sensor chips, we concluded the good selectivity of the sensor for LPS detection. In addition, the sensor shows feasibility for the detection of LPS in commonly used clinical injectable fluids, such as clinical-grade 0.9% sodium chloride intravenous infusion, compound sodium lactate intravenous infusion and insulin aspart. The developed sensor platform offers the advantage of portability and simplicity, which is attractive for point-of-care and remote detection of biomedical and environmental targets.
author2 School of Materials Science & Engineering
author_facet School of Materials Science & Engineering
Zhang, Jinling
Khan, Imran
Zhang, Qingwen
Liu, Xiaohu
Dostalek, Jakub
Liedberg, Bo
Wang, Yi
format Article
author Zhang, Jinling
Khan, Imran
Zhang, Qingwen
Liu, Xiaohu
Dostalek, Jakub
Liedberg, Bo
Wang, Yi
author_sort Zhang, Jinling
title Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
title_short Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
title_full Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
title_fullStr Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
title_full_unstemmed Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
title_sort lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
publishDate 2020
url https://hdl.handle.net/10356/139808
_version_ 1681058946253586432