Structural studies of human telomerase complexes by cryo-electron microscopy
Chromosomal DNA ends shorten after each round of replication due to the end-replication problem and post replication processing. The ends of linear eukaryotic chromosomes are capped and protected by protein-DNA complexes forming a structure called the telomere. The telomere length is crucial as cri...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/139941 |
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| Institution: | Nanyang Technological University |
| Language: | English |