Hyaluronan receptor LYVE-1 - expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen

• Main Authors: Lim, Hwee Ying, Lim, Sheau Yng, Tan, Chek Kun, Thiam, Chung Hwee, Goh, Chi Ching, Carbajo, Daniel, Chew, Samantha Hui Shang, See, Peter Chi Ee, Chakarov, Svetoslav, Wang, Xiao Nong, Lim, Li Hui, Johnson, Louise A., Lum, Josephine, Fong, Chui Yee, Ariff Bongso, Arijit Biswas, Goh, Chern, Evrard, Maximilien, Yeo, Kim Pin, Basu, Ranu, Wang, Jun Kit, Tan, Yingrou, Rohit Jain, Tikoo, Shweta, Choong, Cleo S. N., Weninger, Wolfgang, Poidinger, Michael, Stanley, Richard E, Collin, Matthew, Tan, Nguan Soon, Ng, Lai Guan, Jackson, David G., Ginhoux, Florent, Angeli, Véronique
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Macrophage; LYVE-1
• Online Access: https://hdl.handle.net/10356/140056
• Institution: Nanyang Technological University

The maintenance of appropriate arterial tone is critically important for normal physiological arterial function. However, the cellular and molecular mechanisms remain poorly defined. Here, we have shown that in the mouse aorta, resident macrophages prevented arterial stiffness and collagen depositio...