Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect

• Main Authors: Tan, Yang Fei, Lee, Ying Shi, Seet, Li-Fong, Ng, Kee Woei, Wong, Tina T., Venkatraman, Subbu
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Materials; Layer-by-layer Nanoparticles; siRNA Delivery
• Online Access: https://hdl.handle.net/10356/140608
• Institution: Nanyang Technological University

Objectives: Clinical translation of siRNA therapeutics has been severely limited due to the lack of stable and sustained siRNA delivery systems. Furthermore, when nanocarrier systems with siRNA are administered systemically to treat diseases, insufficient doses reach the target tissue. Here we repor...