Probability distribution of genetic codes

• Main Author: Khaw, Elvis Rui En
• Other Authors: Shu Jian Jun
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Engineering::Mechanical engineering
• Online Access: https://hdl.handle.net/10356/140684
• Institution: Nanyang Technological University

The advancement of the hereditary code has consistently been a general puzzle. Various theories were propounded yet none figured out how to build up a persuading clarification for the codon assignments. Hence, this project was done to investigate the development of the hereditary code, giving incredible consideration to the distribution of the codon assignments. In the first section of the project, the current conviction on the hereditary code being a natural language was researched. Following by the literature review of various probability distributions and in which we will discover that it is separated into two classes. Next, numerous examples on how each probability distributions can be applied into the world of genetics are illustrated using Microsoft Excel and graphs. Also, hereditary association concentrates routinely involve huge quantities of measurable tests joined by P-values. Entire genome sequencing advancements expanded the potential number of tried variations to tens of millions. The more tests are played out, the littler P-value is required to be considered significant. However, a little P-value isn't proportional to little odds of a spurious finding and significance thresholds may fail to serve as efficient filters against false results. This project focuses on utilising Microsoft Excel formulas to hypothesis test whether a probability distribution is valid in certain cases. Lastly, a discussion on how important gene finding can be in the world of genetics is also being conducted.