Structural and biochemical studies of erythromycin-resistance methyltransferases : insights into structure-based drug design

• Main Author: Xiang, Xinyu
• Other Authors: Julien Lescar
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/140816
• Institution: Nanyang Technological University

Erm38 is a methyltransferase from Mycolicibacterium smegmatis that methylates the A2058 position in 23S rRNA using S-adenosyl methionine (SAM) as methyl donor. It confers resistance to macrolides, lincosamides and streptogramins in Gram-positive bacteria and mycobacteria. In this project, we obtaine...