Fabrication of poly (butadiene-block-ethylene oxide) based amphiphilic polymersomes : an approach for improved oral pharmacokinetics of Sorafenib

• المؤلفون الرئيسيون: Muhammad Adeeb Khan, Shaukat Ali, Venkatraman, Subbu S., Muhammad Farhan Sohail, Muhammad Ovais, Abida Raza
• مؤلفون آخرون: School of Materials Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Engineering::Materials; Sorafenib; Oral Delivery
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/141202
• المؤسسة: Nanyang Technological University

Sorafenib (SFN), a hydrophobic anticancer drug, has several limitations predominantly poor aqueous solubility and hepatic first-pass effect, limiting its oral delivery that results into several other complications. Present study aims to develop Sorafenib loaded polymersomes using poly butadiene bloc...