Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants

A novel custom-made 3D silicone printer and two-part Ecoflex silicone resins were used to 3D-print standard-shaped silicone coupon and irregular-shaped meniscus structures via a heat-cured extrusion-based method. This article is segmented into three parts: (1) study on the effect of 3D printing para...

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Main Authors: Luis, Eric, Pan, Houwen Matthew, Sing, Swee Leong, Bastola, Anil Kumar, Goh, Guo Dong, Goh, Guo Liang, Tan, Joel Heang Kuan, Bajpai, Ram, Song, Juha, Yeong, Wai Yee
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/141419
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1414192020-09-26T22:08:11Z Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants Luis, Eric Pan, Houwen Matthew Sing, Swee Leong Bastola, Anil Kumar Goh, Guo Dong Goh, Guo Liang Tan, Joel Heang Kuan Bajpai, Ram Song, Juha Yeong, Wai Yee School of Chemical and Biomedical Engineering School of Mechanical and Aerospace Engineering Lee Kong Chian School of Medicine (LKCMedicine) Center for Population Health Sciences Singapore Centre for 3D Printing Engineering::Mechanical engineering Additive Manufacturing 3D Printing A novel custom-made 3D silicone printer and two-part Ecoflex silicone resins were used to 3D-print standard-shaped silicone coupon and irregular-shaped meniscus structures via a heat-cured extrusion-based method. This article is segmented into three parts: (1) study on the effect of 3D printing parameters on dimensional accuracy and mechanical properties of 3D-printed silicone, (2) reliability and failure analysis of 3D-printed silicone according to ASTM D575 standards under monotonic and cyclic compressive loading, and (3) cytotoxicity of 3D-printed silicone by extraction method according to ISO 10993-12 for different extraction time and extract volume/surface area ratios. Based on analysis using regression method and analysis of variance, we found that the dimensional accuracy of lengths and widths is sensitive to both nozzle diameters and bed temperatures (BTs), while the height is only sensitive to BTs. Failure results were analyzed using the two-parameter Weibull probability distribution model and Weibull regression analysis and revealed that the Weibull modulus had a value greater than 1 in all groups, indicating an increasing failure rate with time for Ecoflex 30 and 50 meniscus implants. Results from quantitative cell proliferative assay exhibit statistically insignificant differences for all samples, pointing to the low cytotoxicity and excellent biocompatibility of printed silicone. Accepted version This research is supported by the National Research Foundation, Prime Minister’s Office, Singapore, under its Medium-Sized Centre funding scheme and by the NTU StartUp Grant. 2020-06-08T06:37:15Z 2020-06-08T06:37:15Z 2019 Journal Article Luis, E., Pan, H. M., Sing, S. L., Bastola, A. K., Goh, G. D., Goh, G. L., . . . Yeong, W. Y. (2019). Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants. 3D Printing and Additive Manufacturing, 6(6), 319-332. doi:10.1089/3dp.2018.0226 2329-7662 https://hdl.handle.net/10356/141419 10.1089/3dp.2018.0226 2-s2.0-85077080738 6 6 319 332 en 3D Printing and Additive Manufacturing © 2019 Mary Ann Liebert, Inc. All rights reserved. This paper was published in 3D Printing and Additive Manufacturing and is made available with permission of Mary Ann Liebert, Inc. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Engineering::Mechanical engineering
Additive Manufacturing
3D Printing
spellingShingle Engineering::Mechanical engineering
Additive Manufacturing
3D Printing
Luis, Eric
Pan, Houwen Matthew
Sing, Swee Leong
Bastola, Anil Kumar
Goh, Guo Dong
Goh, Guo Liang
Tan, Joel Heang Kuan
Bajpai, Ram
Song, Juha
Yeong, Wai Yee
Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants
description A novel custom-made 3D silicone printer and two-part Ecoflex silicone resins were used to 3D-print standard-shaped silicone coupon and irregular-shaped meniscus structures via a heat-cured extrusion-based method. This article is segmented into three parts: (1) study on the effect of 3D printing parameters on dimensional accuracy and mechanical properties of 3D-printed silicone, (2) reliability and failure analysis of 3D-printed silicone according to ASTM D575 standards under monotonic and cyclic compressive loading, and (3) cytotoxicity of 3D-printed silicone by extraction method according to ISO 10993-12 for different extraction time and extract volume/surface area ratios. Based on analysis using regression method and analysis of variance, we found that the dimensional accuracy of lengths and widths is sensitive to both nozzle diameters and bed temperatures (BTs), while the height is only sensitive to BTs. Failure results were analyzed using the two-parameter Weibull probability distribution model and Weibull regression analysis and revealed that the Weibull modulus had a value greater than 1 in all groups, indicating an increasing failure rate with time for Ecoflex 30 and 50 meniscus implants. Results from quantitative cell proliferative assay exhibit statistically insignificant differences for all samples, pointing to the low cytotoxicity and excellent biocompatibility of printed silicone.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Luis, Eric
Pan, Houwen Matthew
Sing, Swee Leong
Bastola, Anil Kumar
Goh, Guo Dong
Goh, Guo Liang
Tan, Joel Heang Kuan
Bajpai, Ram
Song, Juha
Yeong, Wai Yee
format Article
author Luis, Eric
Pan, Houwen Matthew
Sing, Swee Leong
Bastola, Anil Kumar
Goh, Guo Dong
Goh, Guo Liang
Tan, Joel Heang Kuan
Bajpai, Ram
Song, Juha
Yeong, Wai Yee
author_sort Luis, Eric
title Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants
title_short Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants
title_full Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants
title_fullStr Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants
title_full_unstemmed Silicone 3D printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants
title_sort silicone 3d printing : process optimization, product biocompatibility, and reliability of silicone meniscus implants
publishDate 2020
url https://hdl.handle.net/10356/141419
_version_ 1681059535603630080