Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation

• Main Authors: Smith, Raymond A. A., Chua, R. J. E., Carnachan, Susan M., Tan, Clarissa L. L., Sims, Ian M., Hinkley, Simon F. R., Nurcombe, Victor, Cool, Simon M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Glycosaminoglycan; Sterilization
• Online Access: https://hdl.handle.net/10356/141441
• Institution: Nanyang Technological University

Heparan sulfate (HS) is a highly heterogeneous polysaccharide implicated in many important biological processes. Our previous work has demonstrated that a particular affinity-selected HS (referred to henceforth as “HS3”) is capable of enhancing the osteogenic effects of bone morphogenetic protein 2...