Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model
In this study, we evaluated the surface characterization of a novel chitosan-silica hybridized membrane and highlighted the substantial role of silica in the wound environment. The chemical coupling of chitosan and silica resulted in a more condensed network compared with pure chitosan, which was ev...
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sg-ntu-dr.10356-1415482020-06-09T03:57:13Z Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model Park, Ji-Ung Jeong, Seol-Ha Song, Eun-Ho Song, Juha Kim, Hyoun-Ee Kim, Sukwha School of Chemical and Biomedical Engineering Engineering::Chemical engineering Chitosan Chitosan–silica In this study, we evaluated the surface characterization of a novel chitosan-silica hybridized membrane and highlighted the substantial role of silica in the wound environment. The chemical coupling of chitosan and silica resulted in a more condensed network compared with pure chitosan, which was eventually able to stably maintain its framework, particularly in the wet state. In addition, we closely observed the wound-healing process along with the surface interaction between chitosan-silica and the wound site using large-surface-area wounds in a porcine model. Our evidence indicates that chitosan-silica exerts a synergetic effect of both materials to promote a remarkable wound-healing process. In particular, the silica in chitosan-silica accelerated wound closure including wound contraction, and re-epithelialization via enhancement of cell recruitment, epidermal maturity, neovascularization, and granulation tissue formation compared with pure chitosan and other commercial dressing materials. This advanced wound dressing material may lead to effective treatment for problematic cutaneous wounds and can be further applied for human skin regeneration. 2020-06-09T03:57:13Z 2020-06-09T03:57:13Z 2018 Journal Article Park, J.-U., Jeong, S.-H., Song, E.-H., Song, J., Kim, H.-E., & Kim, S. (2018). Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model. Journal of Biomaterials Applications, 32(8), 1011-1023. doi:10.1177/0885328217751246 0885-3282 https://hdl.handle.net/10356/141548 10.1177/0885328217751246 29357774 2-s2.0-85042129583 8 32 1011 1023 en Journal of Biomaterials Applications © 2018 The Author(s). All rights reserved. |
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Engineering::Chemical engineering Chitosan Chitosan–silica Park, Ji-Ung Jeong, Seol-Ha Song, Eun-Ho Song, Juha Kim, Hyoun-Ee Kim, Sukwha Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model |
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In this study, we evaluated the surface characterization of a novel chitosan-silica hybridized membrane and highlighted the substantial role of silica in the wound environment. The chemical coupling of chitosan and silica resulted in a more condensed network compared with pure chitosan, which was eventually able to stably maintain its framework, particularly in the wet state. In addition, we closely observed the wound-healing process along with the surface interaction between chitosan-silica and the wound site using large-surface-area wounds in a porcine model. Our evidence indicates that chitosan-silica exerts a synergetic effect of both materials to promote a remarkable wound-healing process. In particular, the silica in chitosan-silica accelerated wound closure including wound contraction, and re-epithelialization via enhancement of cell recruitment, epidermal maturity, neovascularization, and granulation tissue formation compared with pure chitosan and other commercial dressing materials. This advanced wound dressing material may lead to effective treatment for problematic cutaneous wounds and can be further applied for human skin regeneration. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Park, Ji-Ung Jeong, Seol-Ha Song, Eun-Ho Song, Juha Kim, Hyoun-Ee Kim, Sukwha |
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Article |
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Park, Ji-Ung Jeong, Seol-Ha Song, Eun-Ho Song, Juha Kim, Hyoun-Ee Kim, Sukwha |
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Park, Ji-Ung |
title |
Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model |
title_short |
Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model |
title_full |
Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model |
title_fullStr |
Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model |
title_full_unstemmed |
Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model |
title_sort |
acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model |
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2020 |
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https://hdl.handle.net/10356/141548 |
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1681059215943139328 |