Design and prototyping of biomedical device

Biomedical diagnostic and analysis are typically performed in large-scale central laboratories where lot of bulky equipment and reagents are needed. Microfluidics is a rapid developing technology and has many applications. Microfluidics chip is a tiny platform and one of its suitable application is...

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Main Author: He, Linwei
Other Authors: Li King Ho Holden
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2020
Subjects:
Online Access:https://hdl.handle.net/10356/141566
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1415662023-03-04T18:19:40Z Design and prototyping of biomedical device He, Linwei Li King Ho Holden School of Mechanical and Aerospace Engineering HoldenLi@ntu.edu.sg Engineering::Manufacturing Engineering::Bioengineering Engineering::Mechanical engineering Biomedical diagnostic and analysis are typically performed in large-scale central laboratories where lot of bulky equipment and reagents are needed. Microfluidics is a rapid developing technology and has many applications. Microfluidics chip is a tiny platform and one of its suitable application is in biomedical diagnostics and analysis. It can help to miniaturize the sample preparation and analysis into simplified operation on a small microfluidic chip in a portable desktop system. One of this application is cell lysis which breaks the cell membrane walls before the DNA molecules or other organic analytes such as proteins etc in organic samples can be extracted for further analysis or diagnostics. In this project, a cell lysis station is designed to integrate the optical energy from LED light source and mechanical grinding force induced by spinning magnetic field on the in-situ rotating magnetic beads in order to break the cell membrane walls of organic samples inside the microfluidic chip to release the target DNA molecules or other proteins for subsequent analysis and diagnostic. This portable cell lysis station was simulated and designed using a computer aided design (CAD) software SolidWork and was constructed using 3D printing rapid prototyping tool. The novel design of this cell lysis station is the inter-changeable stationary magnetic field or rapid rotating magnetic field together with the optical energy for cell lysis. This ability helps to broaden the cell lysis capability on different variety of cells. The use of microfluidic chip for sample handling allows it to be integrated with other portable microfluidic diagnostic and analysis system Besides, as a, this customer driven design is compact and portable with overall sze of 200 mm x 150 mm x 150 mm, using portable battery bank and no external wired electrical connection is needed during operation. This gives the users a lot of benefits and they can easily carry this cell lysis station to anywhere for the experiments. Bachelor of Engineering (Mechanical Engineering) 2020-06-09T05:11:39Z 2020-06-09T05:11:39Z 2020 Final Year Project (FYP) https://hdl.handle.net/10356/141566 en A015 application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Manufacturing
Engineering::Bioengineering
Engineering::Mechanical engineering
spellingShingle Engineering::Manufacturing
Engineering::Bioengineering
Engineering::Mechanical engineering
He, Linwei
Design and prototyping of biomedical device
description Biomedical diagnostic and analysis are typically performed in large-scale central laboratories where lot of bulky equipment and reagents are needed. Microfluidics is a rapid developing technology and has many applications. Microfluidics chip is a tiny platform and one of its suitable application is in biomedical diagnostics and analysis. It can help to miniaturize the sample preparation and analysis into simplified operation on a small microfluidic chip in a portable desktop system. One of this application is cell lysis which breaks the cell membrane walls before the DNA molecules or other organic analytes such as proteins etc in organic samples can be extracted for further analysis or diagnostics. In this project, a cell lysis station is designed to integrate the optical energy from LED light source and mechanical grinding force induced by spinning magnetic field on the in-situ rotating magnetic beads in order to break the cell membrane walls of organic samples inside the microfluidic chip to release the target DNA molecules or other proteins for subsequent analysis and diagnostic. This portable cell lysis station was simulated and designed using a computer aided design (CAD) software SolidWork and was constructed using 3D printing rapid prototyping tool. The novel design of this cell lysis station is the inter-changeable stationary magnetic field or rapid rotating magnetic field together with the optical energy for cell lysis. This ability helps to broaden the cell lysis capability on different variety of cells. The use of microfluidic chip for sample handling allows it to be integrated with other portable microfluidic diagnostic and analysis system Besides, as a, this customer driven design is compact and portable with overall sze of 200 mm x 150 mm x 150 mm, using portable battery bank and no external wired electrical connection is needed during operation. This gives the users a lot of benefits and they can easily carry this cell lysis station to anywhere for the experiments.
author2 Li King Ho Holden
author_facet Li King Ho Holden
He, Linwei
format Final Year Project
author He, Linwei
author_sort He, Linwei
title Design and prototyping of biomedical device
title_short Design and prototyping of biomedical device
title_full Design and prototyping of biomedical device
title_fullStr Design and prototyping of biomedical device
title_full_unstemmed Design and prototyping of biomedical device
title_sort design and prototyping of biomedical device
publisher Nanyang Technological University
publishDate 2020
url https://hdl.handle.net/10356/141566
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