Biomimetic fetal rotation bioreactor for engineering bone tissues — effect of cyclic strains on upregulation of osteogenic gene expression

• Main Authors: Ravichandran, Akhilandeshwari, Wen, Feng, Lim, Jing, Chong, Mark Seow Khoon, Chan, Jerry K. Y., Teoh, Swee-Hin
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering; Bioreactor; Bioresorbable Scaffolds
• Online Access: https://hdl.handle.net/10356/141580
• Institution: Nanyang Technological University

Cells respond to physiological mechanical stresses especially during early fetal development. Adopting a biomimetic approach, it is necessary to develop bioreactor systems to explore the effects of physiologically relevant mechanical strains and shear stresses for functional tissue growth and develo...