Polymeric nonviral gene delivery systems for cancer immunotherapy

Unlike viral vectors with their undesired safety or immunogenicity concerns, biocompatible polymeric nonviral vectors as gene delivery systems are more promising in gene or cell therapy. Evidence has demonstrated that the rational design of polymeric nonviral gene vectors with optimal structure, cha...

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Main Authors: Ke, Lingjie, Cai, Pingqiang, Wu, Yun‐Long, Chen, Xiaodong
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/141664
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1416642023-07-14T15:48:53Z Polymeric nonviral gene delivery systems for cancer immunotherapy Ke, Lingjie Cai, Pingqiang Wu, Yun‐Long Chen, Xiaodong School of Materials Science and Engineering Engineering::Materials Cationic Polymers Gene Delivery Unlike viral vectors with their undesired safety or immunogenicity concerns, biocompatible polymeric nonviral vectors as gene delivery systems are more promising in gene or cell therapy. Evidence has demonstrated that the rational design of polymeric nonviral gene vectors with optimal structure, charge density, biocompatibility, and stimulus responsiveness can deliver therapeutic genes or gene vaccines (in terms of deoxyribonucleic acid DNA or ribonucleic acid RNA) into tumor‐associated immunocytes (i.e., macrophages, T cells, or dendritic cells) in an effective and controllable manner for enhanced cancer immunotherapy. However, a timely and systematic summary of this subject is lacking. This review presents an overview of polymeric nonviral carriers with immune cell transfection ability and their potential applications in cancer immunotherapy; it also provides a tutorial for designing polymeric immune‐cell genetic modification vector, although there are still few vectors in the product pipeline. With the rapid growth of immunotherapy in cancer treatment and knowledge accumulation in vector structure design, polymeric nonviral gene delivery systems may provide new hope for tumor therapy. NRF (Natl Research Foundation, S’pore) Accepted version 2020-06-10T02:06:25Z 2020-06-10T02:06:25Z 2020 Journal Article Ke, L., Cai, P., Wu, Y.-L., & Chen, X. (2020). Polymeric nonviral gene delivery systems for cancer immunotherapy. Advanced Therapeutics, 3(6), 1900213-. doi:10.1002/adtp.201900213 2366-3987 https://hdl.handle.net/10356/141664 10.1002/adtp.201900213 6 3 1900213 (1 of 22) 1900213 (22 of 22) en Advanced Therapeutics This is the peer reviewed version of the following article: Ke, L., Cai, P., Wu, Y.-L., & Chen, X. (2020). Polymeric nonviral gene delivery systems for cancer immunotherapy. Advanced Therapeutics, 3(6), 1900213-, which has been published in final form at https://doi.org/10.1002/adtp.201900213. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Materials
Cationic Polymers
Gene Delivery
spellingShingle Engineering::Materials
Cationic Polymers
Gene Delivery
Ke, Lingjie
Cai, Pingqiang
Wu, Yun‐Long
Chen, Xiaodong
Polymeric nonviral gene delivery systems for cancer immunotherapy
description Unlike viral vectors with their undesired safety or immunogenicity concerns, biocompatible polymeric nonviral vectors as gene delivery systems are more promising in gene or cell therapy. Evidence has demonstrated that the rational design of polymeric nonviral gene vectors with optimal structure, charge density, biocompatibility, and stimulus responsiveness can deliver therapeutic genes or gene vaccines (in terms of deoxyribonucleic acid DNA or ribonucleic acid RNA) into tumor‐associated immunocytes (i.e., macrophages, T cells, or dendritic cells) in an effective and controllable manner for enhanced cancer immunotherapy. However, a timely and systematic summary of this subject is lacking. This review presents an overview of polymeric nonviral carriers with immune cell transfection ability and their potential applications in cancer immunotherapy; it also provides a tutorial for designing polymeric immune‐cell genetic modification vector, although there are still few vectors in the product pipeline. With the rapid growth of immunotherapy in cancer treatment and knowledge accumulation in vector structure design, polymeric nonviral gene delivery systems may provide new hope for tumor therapy.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Ke, Lingjie
Cai, Pingqiang
Wu, Yun‐Long
Chen, Xiaodong
format Article
author Ke, Lingjie
Cai, Pingqiang
Wu, Yun‐Long
Chen, Xiaodong
author_sort Ke, Lingjie
title Polymeric nonviral gene delivery systems for cancer immunotherapy
title_short Polymeric nonviral gene delivery systems for cancer immunotherapy
title_full Polymeric nonviral gene delivery systems for cancer immunotherapy
title_fullStr Polymeric nonviral gene delivery systems for cancer immunotherapy
title_full_unstemmed Polymeric nonviral gene delivery systems for cancer immunotherapy
title_sort polymeric nonviral gene delivery systems for cancer immunotherapy
publishDate 2020
url https://hdl.handle.net/10356/141664
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