Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in vitro and in vivo

Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in vitro and in vivo

Resistance to platinum agents is challenging in cancer treatment with platinum drugs. Such resistant cells prevent effective platinum accumulation intracellular and alter cellular adaptations to survive from cytotoxicity by regulating corresponding proteins expression. Ideal therapeutics should comb...

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Bibliographic Details
Main Authors: Yu, Chang, Ding, Binbin, Zhang, Xinyang, Deng, Xiaoran, Deng, Kerong, Cheng, Ziyong, Xing, Bengang, Jin, Dayong, Ma, Ping'an, Lin, Jun
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Chemistry
Iron Nanoparticles
Cisplatin Resistant
Online Access:https://hdl.handle.net/10356/141679
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/141679

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