Prolonged hypoxia promotes enrichment of cytosolic EZH2 in breast cancer stem cells via a HIF-1α-independent mechanism

• Main Author: Law, Daniel Cheng Lui
• Other Authors: Su I-Hsin
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/142015
• Institution: Nanyang Technological University

Cancer stem cells (CSCs) make up a small subpopulation of the entire tumour. They have the ability to self-renew as well as differentiate into the cells that make up the bulk tumour. Previously, we have demonstrated that EZH2 is highly enriched in the cytosol of breast cancer stem cells (BCSCs), res...