Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans

• Main Authors: Beaudoin-Chabot, Caroline, Wang, Lei, Smarun, Alexey V., Vidović, Dragoslav, Shchepinov, Mikhail S., Thibault, Guillaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Polyunsaturated Fatty Acid (PUFA); Deuterated Fatty Acid
• Online Access: https://hdl.handle.net/10356/142058; https://doi.org/10.21979/N9/MGPD5H
• Institution: Nanyang Technological University

Chemically reinforced essential fatty acids (FAs) promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential FAs with...