Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

• Main Authors: Naito, Tomoki, Ercan, Bilge, Krshnan, Logesvaran, Triebl, Alexander, Koh, Dylan Hong Zheng, Wei, Fan-Yan, Tomizawa, Kazuhito, Torta, Federico Tesio, Wenk, Markus R., Saheki, Yasunori
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Medicine; Cholesterol; GRAMD1
• 在線閱讀: https://hdl.handle.net/10356/142076

Cholesterol is a major structural component of the plasma membrane (PM). The majority of PM cholesterol forms complexes with other PM lipids, making it inaccessible for intracellular transport. Transition of PM cholesterol between accessible and inaccessible pools maintains cellular homeostasis, but...