Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

• المؤلفون الرئيسيون: Naito, Tomoki, Ercan, Bilge, Krshnan, Logesvaran, Triebl, Alexander, Koh, Dylan Hong Zheng, Wei, Fan-Yan, Tomizawa, Kazuhito, Torta, Federico Tesio, Wenk, Markus R., Saheki, Yasunori
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Medicine; Cholesterol; GRAMD1
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142076

Cholesterol is a major structural component of the plasma membrane (PM). The majority of PM cholesterol forms complexes with other PM lipids, making it inaccessible for intracellular transport. Transition of PM cholesterol between accessible and inaccessible pools maintains cellular homeostasis, but...