Insights into the effects of cancer associated mutations at the UPF2 and ATP-binding sites of NMD master regulator : UPF1

• Main Authors: Kalathiya, Umesh, Padariya, Monikaben, Pawlicka, Kamila, Verma, Chandra Shekhar, Houston, Douglas, Hupp, Ted R., Alfaro, Javier Antonio
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; UPF1; ATP-binding Site
• Online Access: https://hdl.handle.net/10356/142155
• Institution: Nanyang Technological University

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that recognizes post-transcriptionally abnormal transcripts and mediates their degradation. The master regulator of NMD is UPF1, an enzyme with intrinsic ATPase and helicase activities. The cancer genomic sequencing data has identifie...