Programme of research for the further development of the sequence- specific integration system from phage lambda for the targeted manipulation of genomes in higher eukaryotes

• Main Author: Droge, Peter
• Other Authors: School of Biological Sciences
• Format: Research Report
• Language: English
• Published: 2008
• Subjects: DRNTU::Science::Biological sciences::Cytology
• Online Access: http://hdl.handle.net/10356/14222
• Institution: Nanyang Technological University

The original objective was to generate human embryonic stem cell line(s) that could be employed for site-specific transgene Insertion into a predetermined genomic locus (target sequence) using our novel phage lambda integrase-based recombination system. Such a system would be useful for many applica...