MMP14 in sarcoma : a regulator of tumor microenvironment communication in connective tissues

• Main Authors: Gonzalez-Molina, Jordi, Gramolelli, Silvia, Liao, Zehuan, Carlson, Joseph W., Ojala, Päivi M., Lehti, Kaisa
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; MMP14; Sarcoma
• Online Access: https://hdl.handle.net/10356/142264
• Institution: Nanyang Technological University

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multipl...