Regulation of the TAK1 and MEKK3 protein kinases in the inflammatory response.

• Main Author: Cheung, Peter.
• Other Authors: School of Biological Sciences
• Format: Research Report
• Language: English
• Published: 2008
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/14227
• Institution: Nanyang Technological University

The present proposal aims to investigate the mechanism of activation of TAKl and MEKK3, two MAP3Ks shown to play key roles in the inflammatory response. Activation of these two protein kinases by the pro-inflammatory cytokines IL-1 and TNFalpha, or by bacterial LPS leads to the expression of pro-inf...