1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity

1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity

The emergence of multi- and extensively-drug resistant tubercular (MDR- and XDR-TB) strains of mycobacteria has limited the use of existing therapies, therefore new drugs are needed. Dihydrofolate reductase (DHFR) has recently attracted much attention as a target for the development of anti-TB agent...

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Bibliographic Details
Main Authors: Yang, Xuan, Wedajo, Wassihun, Yamada, Yoshiyuki, Dahlroth, Sue-Li, Neo, Jason Jun-Long, Dick, Thomas, Chui, Wai-Keung
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Dihydrofolate Reductase
Antimycobacterial Agent
Online Access:https://hdl.handle.net/10356/142311
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/142311

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