Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans
Mutations in pre-synaptic voltage-gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inhibition, the molecular and cellular mechanisms underlying this excitato...
محفوظ في:
المؤلفون الرئيسيون: | Huang, Yung-Chi, Pirri, Jennifer K., Rayes, Diego, Gao, Shangbang, Mulcahy, Ben, Grant, Jeff, Saheki, Yasunori, Francis, Michael M., Zhen, Mei, Alkema, Mark J. |
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مؤلفون آخرون: | Lee Kong Chian School of Medicine (LKCMedicine) |
التنسيق: | مقال |
اللغة: | English |
منشور في: |
2020
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الموضوعات: | |
الوصول للمادة أونلاين: | https://hdl.handle.net/10356/142351 |
الوسوم: |
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