Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates

Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates

The glucagon receptor (GCGR) is an emerging target in anti-diabetic therapy. Reliable biomarkers for in vivo activity on the GCGR, in the setting of dual glucagon-like peptide 1/glucagon (GLP-1/GCG) receptor agonism, are currently unavailable. Here, we investigated [68Ga]Ga-DO3A-S01-GCG as a biomark...

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Main Authors: Eriksson, Olof, Velikyan, Irina, Haack, Torsten, Bossart, Martin, Evers, Andreas, Laitinen, Iina, Larsen, Philip J., Plettenburg, Oliver, Takano, Akihiro, Halldin, Christer, Antoni, Gunnar, Johansson, Lars, Pierrou, Stefan, Wagner, Michael
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Positron Emission Tomography (PET)
Glucagon Receptor (GCGR)
Online Access:https://hdl.handle.net/10356/142352
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/142352

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