The dual interactions of p53 with MDM2 and p300 : implications for the design of MDM2 inhibitors

• المؤلفون الرئيسيون: Kannan, Srinivasaraghavan, Partridge, Anthony William, Lane, David P., Verma, Chandra Shekhar
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Stapled Peptides; PPIs
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142381
• المؤسسة: Nanyang Technological University

Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targeted for inhibition in a variety of cancers. In addition to the development of small molecules, there has been interest in developing constrained (stapled) peptide inhibitors. A stapled peptide ALRN_6924...