The dual interactions of p53 with MDM2 and p300 : implications for the design of MDM2 inhibitors

• Main Authors: Kannan, Srinivasaraghavan, Partridge, Anthony William, Lane, David P., Verma, Chandra Shekhar
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Biological sciences; Stapled Peptides; PPIs
• 在線閱讀: https://hdl.handle.net/10356/142381
• 機構: Nanyang Technological University

Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targeted for inhibition in a variety of cancers. In addition to the development of small molecules, there has been interest in developing constrained (stapled) peptide inhibitors. A stapled peptide ALRN_6924...