Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases

• Main Authors: Park, Tae-Yoon, Jang, Yongwoo, Kim, Woori, Shin, Joon, Toh, Hui Ting, Kim, Chun-Hyung, Yoon, Ho Sup, Leblanc, Pierre, Kim, Kwang-Soo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Chloroquine (CQ); Inflammatory Autoimmune Responses
• Online Access: https://hdl.handle.net/10356/142409
• Institution: Nanyang Technological University

For over a half-century the anti-malarial drug chloroquine (CQ) has been used as a therapeutic agent, alone or in combination, to treat autoimmune diseases. However, neither the underlying mechanism(s) of action nor their molecular target(s) are well defined. The orphan nuclear receptor Nurr1 (also...