Dengue virus – elicited tryptase induces endothelial permeability and shock

• Main Authors: Rathore, Abhay P. S., Mantri, Chinmay Kumar, Aman, Siti A. B., Syenina, Ayesa, Ooi, Justin, Jagaraj, Cyril J., Goh, Chi Ching, Tissera, Hasitha, Wilder-Smith, Annelies, Ng, Lai Guan, Gubler, Duane J., St. John, Ashley L.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Dengue Virus (DENV); Dengue Hemorrhagic Fever (DHF)
• Online Access: https://hdl.handle.net/10356/142486
• Institution: Nanyang Technological University

Dengue virus (DENV) infection causes a characteristic pathology in humans involving dysregulation of the vascular system. In some patients with dengue hemorrhagic fever (DHF), vascular pathology can become severe, resulting in extensive microvascular permeability and plasma leakage into tissues and...