Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fbrils

• Main Authors: Kannaian, Bhuvaneswari, Sharma, Bhargy, Phillips, Margaret, Chowdhury, Anup, Manimekalai, Malathy Sony Subramanian, Adav, Sunil Shankar, Ng, Justin Tze Yang, Kumar, Ambrish, Lim, Sierin, Mu, Yuguang, Sze, Siu Kwan, Grüber, Gerhard, Pervushin, Konstantin
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Chaperones; Structural Biology
• Online Access: https://hdl.handle.net/10356/142559
• Institution: Nanyang Technological University

Misfolding of Amyloid β (Aβ) peptides leads to the formation of extracellular amyloid plaques. Molecular chaperones can facilitate the refolding or degradation of such misfolded proteins. Here, for the first time, we report the unique ability of Lipocalin-type Prostaglandin D synthase (L-PGDS) prote...