Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model
Optical coherence tomography angiography (OCTA) is a well-established non-invasive retinal vascular imaging technique. It has been recently adapted to image the anterior segment and has shown good potential to image corneal vascularisation. The purpose of the study is to evaluate the usefulness of O...
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sg-ntu-dr.10356-1426142020-11-01T05:30:29Z Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model Devarajan, Kavya Ong, Hon Shing Lwin, Nyein C. Chua, Jacqueline Schmetterer, Leopold Mehta, Jodhbir Singh Ang, Marcus School of Materials Science and Engineering Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Optical Coherence Tomography Angiography (OCTA) Corneal Vascularization Optical coherence tomography angiography (OCTA) is a well-established non-invasive retinal vascular imaging technique. It has been recently adapted to image the anterior segment and has shown good potential to image corneal vascularisation. The purpose of the study is to evaluate the usefulness of OCTA to monitor regression of corneal vessels following anti-VEGF (vascular endothelial growth factor) treatment using a previously established corneal vascularisation rabbit model. The regression of vessels following the treatment with aflibercept and ranibizumab anti-VEGFs using both topical instillation and sub-conjunctival injection was quantified using OCTA and compared with ICGA (indocyanine green angiography). Overall vessel density measurements using OCTA showed good correlation (r = 0.988, p < 0.001) with ICGA, with no significant difference between the two treatment groups (p = 0.795). It was also shown that OCTA provided good repeatability outcomes of the quantitative measurements. Using Bland-Altman plots, vessel growth density values between anti-VEGF treatments were compared to control saline group. It was observed that aflibercept provided longer lasting effect than ranibizumab. We also observed that in both drugs, the topical route of administration topical provided longer regression outcomes compared to one-time sub-conjunctival injection. Thereby, with this pilot study, it was demonstrated that OCTA is a reliable imaging technique to follow-up and monitor corneal vascularisation and its treatment quantitatively. Published version 2020-06-25T07:57:47Z 2020-06-25T07:57:47Z 2019 Journal Article Devarajan, K., Ong, H. S., Lwin, N. C., Chua, J., Schmetterer, L., Mehta, J. S., & Ang, M. (2019). Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model. Scientific Reports, 9(1), 17576-. doi:10.1038/s41598-019-54171-5 2045-2322 https://hdl.handle.net/10356/142614 10.1038/s41598-019-54171-5 31772259 2-s2.0-85075619110 1 9 en Scientific Reports © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
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Science::Medicine Optical Coherence Tomography Angiography (OCTA) Corneal Vascularization Devarajan, Kavya Ong, Hon Shing Lwin, Nyein C. Chua, Jacqueline Schmetterer, Leopold Mehta, Jodhbir Singh Ang, Marcus Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model |
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Optical coherence tomography angiography (OCTA) is a well-established non-invasive retinal vascular imaging technique. It has been recently adapted to image the anterior segment and has shown good potential to image corneal vascularisation. The purpose of the study is to evaluate the usefulness of OCTA to monitor regression of corneal vessels following anti-VEGF (vascular endothelial growth factor) treatment using a previously established corneal vascularisation rabbit model. The regression of vessels following the treatment with aflibercept and ranibizumab anti-VEGFs using both topical instillation and sub-conjunctival injection was quantified using OCTA and compared with ICGA (indocyanine green angiography). Overall vessel density measurements using OCTA showed good correlation (r = 0.988, p < 0.001) with ICGA, with no significant difference between the two treatment groups (p = 0.795). It was also shown that OCTA provided good repeatability outcomes of the quantitative measurements. Using Bland-Altman plots, vessel growth density values between anti-VEGF treatments were compared to control saline group. It was observed that aflibercept provided longer lasting effect than ranibizumab. We also observed that in both drugs, the topical route of administration topical provided longer regression outcomes compared to one-time sub-conjunctival injection. Thereby, with this pilot study, it was demonstrated that OCTA is a reliable imaging technique to follow-up and monitor corneal vascularisation and its treatment quantitatively. |
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School of Materials Science and Engineering |
author_facet |
School of Materials Science and Engineering Devarajan, Kavya Ong, Hon Shing Lwin, Nyein C. Chua, Jacqueline Schmetterer, Leopold Mehta, Jodhbir Singh Ang, Marcus |
format |
Article |
author |
Devarajan, Kavya Ong, Hon Shing Lwin, Nyein C. Chua, Jacqueline Schmetterer, Leopold Mehta, Jodhbir Singh Ang, Marcus |
author_sort |
Devarajan, Kavya |
title |
Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model |
title_short |
Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model |
title_full |
Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model |
title_fullStr |
Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model |
title_full_unstemmed |
Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model |
title_sort |
optical coherence tomography angiography imaging to monitor anti-vegf treatment of corneal vascularization in a rabbit model |
publishDate |
2020 |
url |
https://hdl.handle.net/10356/142614 |
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1683494418706857984 |