Impact of free cancer predisposition cascade genetic testing on uptake in Singapore

Cascade testing for cancer predisposition offers a highly efficient and cost-effective method for identifying individuals at increased risk for cancer, in whom targeted interventions can often improve survival. The aim of this study was to determine the impact of free cascade testing on uptake and i...

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Main Authors: Courtney, Eliza, Chok, Amanda Kay-Lyn, Ang, Zoe Li Ting, Shaw, Tarryn, Li, Shao-Tzu, Yuen, Jeanette, Ngeow, Joanne
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/142632
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1426322020-11-01T05:10:43Z Impact of free cancer predisposition cascade genetic testing on uptake in Singapore Courtney, Eliza Chok, Amanda Kay-Lyn Ang, Zoe Li Ting Shaw, Tarryn Li, Shao-Tzu Yuen, Jeanette Ngeow, Joanne Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Genetic Cancer Cascade testing for cancer predisposition offers a highly efficient and cost-effective method for identifying individuals at increased risk for cancer, in whom targeted interventions can often improve survival. The aim of this study was to determine the impact of free cascade testing on uptake and identify other associated factors. Demographic and clinical data were gathered prospectively for 183 probands found to have a pathogenic variant associated with cancer predisposition and their 826 first-degree relatives (FDRs). The provision of free cascade testing was significantly associated with uptake (21.6% vs 6.1%; χ2, P < 0.001). Relationship type between FDR and proband and FDR age also demonstrated significant associations, suggesting greater engagement amongst younger generations. Overall, 29.0% (53/183) of families had at least 1 FDR who underwent cascade testing. Of these families, 67.9% (36/53) had an uptake rate of at least 40.0%. Cost is a significant barrier to cascade testing uptake in Singapore. Tailored interventions targeting underrepresented groups and genetic counseling approaches supporting family communication and decision-making are necessary. NMRC (Natl Medical Research Council, S’pore) Published version 2020-06-26T01:12:39Z 2020-06-26T01:12:39Z 2019 Journal Article Courtney, E., Chok, A. K.-L., Ang, Z. L. T., Shaw, T., Li, S.-T., Yuen, J., & Ngeow, J. (2019). Impact of free cancer predisposition cascade genetic testing on uptake in Singapore. npj Genomic Medicine, 4(1), 22-. doi:10.1038/s41525-019-0096-5 2056-7944 https://hdl.handle.net/10356/142632 10.1038/s41525-019-0096-5 31531230 2-s2.0-85072996788 1 4 en npj Genomic Medicine © 2019 The Author(s). Published in partnership with CEGMR, King Abdulaziz University. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Genetic
Cancer
spellingShingle Science::Medicine
Genetic
Cancer
Courtney, Eliza
Chok, Amanda Kay-Lyn
Ang, Zoe Li Ting
Shaw, Tarryn
Li, Shao-Tzu
Yuen, Jeanette
Ngeow, Joanne
Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
description Cascade testing for cancer predisposition offers a highly efficient and cost-effective method for identifying individuals at increased risk for cancer, in whom targeted interventions can often improve survival. The aim of this study was to determine the impact of free cascade testing on uptake and identify other associated factors. Demographic and clinical data were gathered prospectively for 183 probands found to have a pathogenic variant associated with cancer predisposition and their 826 first-degree relatives (FDRs). The provision of free cascade testing was significantly associated with uptake (21.6% vs 6.1%; χ2, P < 0.001). Relationship type between FDR and proband and FDR age also demonstrated significant associations, suggesting greater engagement amongst younger generations. Overall, 29.0% (53/183) of families had at least 1 FDR who underwent cascade testing. Of these families, 67.9% (36/53) had an uptake rate of at least 40.0%. Cost is a significant barrier to cascade testing uptake in Singapore. Tailored interventions targeting underrepresented groups and genetic counseling approaches supporting family communication and decision-making are necessary.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Courtney, Eliza
Chok, Amanda Kay-Lyn
Ang, Zoe Li Ting
Shaw, Tarryn
Li, Shao-Tzu
Yuen, Jeanette
Ngeow, Joanne
format Article
author Courtney, Eliza
Chok, Amanda Kay-Lyn
Ang, Zoe Li Ting
Shaw, Tarryn
Li, Shao-Tzu
Yuen, Jeanette
Ngeow, Joanne
author_sort Courtney, Eliza
title Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
title_short Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
title_full Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
title_fullStr Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
title_full_unstemmed Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
title_sort impact of free cancer predisposition cascade genetic testing on uptake in singapore
publishDate 2020
url https://hdl.handle.net/10356/142632
_version_ 1683493006086242304