Novel insights into the localization and functions of tripartite motif-containing 22

Novel insights into the localization and functions of tripartite motif-containing 22

Tripartite motif-containing 22 (TRIM22) is an interferon (IFN)- and p53-inducible gene product previously shown to possess antiviral and growth inhibitory properties. Microarray analyses in progesterone receptor-positive and estrogen receptor-negative breast cancer cells (ABC28) revealed that proges...

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Main Author: Gayathri, Sivaramakrishnan
Other Authors: Valerie Lin Chun Ling
Format: Theses and Dissertations
Language:English
Published: 2008
Subjects:
DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology
Online Access:https://hdl.handle.net/10356/14266
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-142662023-02-28T18:41:12Z Novel insights into the localization and functions of tripartite motif-containing 22 Gayathri, Sivaramakrishnan Valerie Lin Chun Ling School of Biological Sciences DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology Tripartite motif-containing 22 (TRIM22) is an interferon (IFN)- and p53-inducible gene product previously shown to possess antiviral and growth inhibitory properties. Microarray analyses in progesterone receptor-positive and estrogen receptor-negative breast cancer cells (ABC28) revealed that progesterone dramatically enhances levels of the TRIM22 transcript. Since progesterone inhibits the growth of breast cancer cells, the aim of this study was to generate specific antibodies against TRIM22, to investigate TRIM22’s function, and to investigate if TRIM22 mediated progesterone’s growth inhibitory effect in breast cancer cells. DOCTOR OF PHILOSOPHY (SBS) 2008-11-12T06:02:33Z 2008-11-12T06:02:33Z 2008 2008 Thesis Gayathri, S. (2008). Novel insights into the localization and functions of tripartite motif-containing 22. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/14266 10.32657/10356/14266 en 267 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology
spellingShingle DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology
Gayathri, Sivaramakrishnan
Novel insights into the localization and functions of tripartite motif-containing 22
description Tripartite motif-containing 22 (TRIM22) is an interferon (IFN)- and p53-inducible gene product previously shown to possess antiviral and growth inhibitory properties. Microarray analyses in progesterone receptor-positive and estrogen receptor-negative breast cancer cells (ABC28) revealed that progesterone dramatically enhances levels of the TRIM22 transcript. Since progesterone inhibits the growth of breast cancer cells, the aim of this study was to generate specific antibodies against TRIM22, to investigate TRIM22’s function, and to investigate if TRIM22 mediated progesterone’s growth inhibitory effect in breast cancer cells.
author2 Valerie Lin Chun Ling
author_facet Valerie Lin Chun Ling
Gayathri, Sivaramakrishnan
format Theses and Dissertations
author Gayathri, Sivaramakrishnan
author_sort Gayathri, Sivaramakrishnan
title Novel insights into the localization and functions of tripartite motif-containing 22
title_short Novel insights into the localization and functions of tripartite motif-containing 22
title_full Novel insights into the localization and functions of tripartite motif-containing 22
title_fullStr Novel insights into the localization and functions of tripartite motif-containing 22
title_full_unstemmed Novel insights into the localization and functions of tripartite motif-containing 22
title_sort novel insights into the localization and functions of tripartite motif-containing 22
publishDate 2008
url https://hdl.handle.net/10356/14266
_version_ 1759855678561714176

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