Studying the recognition mechanism of TcaR and ssDNA using molecular dynamic simulations

• Main Authors: Fan, Jing-rong, Zhang, Hong-xing, Mu, Yu-guang, Zheng, Qing-chuan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; TcaR; Recognition Mechanism
• Online Access: https://hdl.handle.net/10356/142670
• Institution: Nanyang Technological University

The transcription regulator teicoplanin-associate locus regulator (TcaR) plays a vital role in interfering with ssDNA replication and resisting ssDNA phage invasion. Although recent studies demonstrated that TcaR had strong interaction with ssDNA, the dynamics and interaction mechanism of dimeric Tc...