Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein

• Main Authors: Zhang, Si Min, Liao, Ying, Neo, Tuan Ling, Lu, Yanning, Liu, Ding Xiang, Vahlne, Anders, Tam, James Pingkwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Steric β-zipper; SARS-CoV Spike Protein
• Online Access: https://hdl.handle.net/10356/142743
• Institution: Nanyang Technological University

Self-binding peptides containing zipper-like sequences, such as the Leu/Ile zipper sequence within the coiled coil regions of proteins and the cross-β spine steric zippers within the amyloid-like fibrils, could bind to the protein-of-origin through homophilic sequence-specific zipper motifs. These s...