The potential impact of Connexin 43 expression on Bcl-2 protein level and taxane sensitivity in head and neck cancers - in vitro studies

• Main Authors: Gurbi, Bianka, Brauswetter, Diána, Varga, Attila, Gyulavári, Pál, Pénzes, Kinga, Murányi, József, Zámbó, Veronika, Birtalan, Ede, Krenács, Tibor, Becker, David Laurence, Csala, Miklós, Vályi-Nagy, István, Peták, István, Dános, Kornél
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Head and Neck Cancer; Paclitaxel
• Online Access: https://hdl.handle.net/10356/142838
• Institution: Nanyang Technological University

The poor prognosis of head and neck squamous cell carcinoma (HNSCC) is partly due to the lack of reliable predictive markers. Connexin 43 (Cx43) protein and its cell-communication channels have been assigned tumor suppressor functions while the anti-apoptotic Bcl-2 (B-cell lymphoma-2) protein has be...