Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing

• Main Authors: Chin, Jiah Shin, Chooi, Wai Hon, Wang, Hongxia, Ong, William, Leong, Kam W., Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Bioengineering; Gene Delivery; Cas9 Protein
• Online Access: https://hdl.handle.net/10356/142907
• Institution: Nanyang Technological University

Genome editing, especially via the simple and versatile type II CRISPR/Cas9 system, offers an effective avenue to precisely control cell fate, an important aspect of tissue regeneration. Unfortunately, most CRISPR/Cas9 non-viral delivery strategies only utilise micro-/nano-particle delivery methods....