In vitro and in vivo evaluation of an electrospun-aligned microfibrous implant for Annulus fibrosus repair

• Main Authors: Gluais, Maude, Clouet, Johann, Fusellier, Marion, Decante, Cyrille, Moraru, Constantin, Dutilleul, Maeva, Veziers, Joëlle, Lesoeur, Julie, Dumas, Dominique, Abadie, Jérôme, Hamel, Antoine, Bord, Eric, Chew, Sing Yian, Guicheux, Jérôme, Le Visage, Catherine
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Bioengineering; Intervertebral Disc; Herniation
• Online Access: https://hdl.handle.net/10356/142908
• Institution: Nanyang Technological University

Annulus fibrosus (AF) impairment is associated with reherniation, discogenic pain, and disc degeneration after surgical partial discectomy. Due to a limited intrinsic healing capacity, defects in the AF persist over time and it is hence necessary to adopt an appropriate strategy to close and repair...