Adaptation of Plasmodium falciparum in human RBC supplemented NSG mice

• Main Author: Chew, Marvin
• Other Authors: Peter Preiser
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences::Microbiology::Immunology; Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/142942
• Institution: Nanyang Technological University

Human chimeric mouse models, also known as humanized mice, are powerful tools to study human obligate pathogens such as Plasmodium falciparum. In our chimeric mouse model, human RBC supplemented NSG mice, static in vitro cultured P. falciparum require adaptation to become competent to thrive in the...