A self-adhesive microneedle patch with drug loading capability through swelling effect

A self-adhesive microneedle patch with drug loading capability through swelling effect

Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a...

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Bibliographic Details
Main Authors: Chew, Sharon Wan Ting, Shah, Ankur Harish, Zheng, Mengjia, Chang, Hao, Wiraja, Christian, Steele, Terry W. J., Xu, Chenjie
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Engineering::Materials
Bioadhesive
Dendrimer
Online Access:https://hdl.handle.net/10356/143108
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Institution: Nanyang Technological University
Language: English
Description
Summary:Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm-2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.

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