Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups

Purpose To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between nonhabitual and habitual groups due to caffeine intake. Method This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years o...

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Main Authors: Aishah Ismail, Bhatti, Mehwish S., Faye, Ibrahima, Lu, Cheng Kai, Laude, Augustinus, Tang, Tong Boon
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/143144
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1431442020-08-05T05:51:23Z Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups Aishah Ismail Bhatti, Mehwish S. Faye, Ibrahima Lu, Cheng Kai Laude, Augustinus Tang, Tong Boon Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Pulse Waveform Laser Speckle Flowgraphy Purpose To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between nonhabitual and habitual groups due to caffeine intake. Method This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the nonhabitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion The experiment results demonstrated caffeine does modulate OBF significantly and response differently in nonhabitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups. 2020-08-05T05:51:23Z 2020-08-05T05:51:23Z 2018 Journal Article Aishah Ismail, Bhatti, M. S., Faye, I., Lu, C. K., Laude, A., & Tang, T. B. (2018). Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups. Graefe's Archive for Clinical and Experimental Ophthalmology, 256(9), 1711-1721. doi:10.1007/s00417-018-4030-9 0721-832X https://hdl.handle.net/10356/143144 10.1007/s00417-018-4030-9 29876732 2-s2.0-85048041837 9 256 1711 1721 en Graefe's archive for clinical and experimental ophthalmology © 2018 Springer-Verlag GmbH Germany, part of Springer Nature. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Medicine
Pulse Waveform
Laser Speckle Flowgraphy
spellingShingle Science::Medicine
Pulse Waveform
Laser Speckle Flowgraphy
Aishah Ismail
Bhatti, Mehwish S.
Faye, Ibrahima
Lu, Cheng Kai
Laude, Augustinus
Tang, Tong Boon
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
description Purpose To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between nonhabitual and habitual groups due to caffeine intake. Method This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the nonhabitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion The experiment results demonstrated caffeine does modulate OBF significantly and response differently in nonhabitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Aishah Ismail
Bhatti, Mehwish S.
Faye, Ibrahima
Lu, Cheng Kai
Laude, Augustinus
Tang, Tong Boon
format Article
author Aishah Ismail
Bhatti, Mehwish S.
Faye, Ibrahima
Lu, Cheng Kai
Laude, Augustinus
Tang, Tong Boon
author_sort Aishah Ismail
title Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
title_short Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
title_full Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
title_fullStr Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
title_full_unstemmed Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
title_sort pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
publishDate 2020
url https://hdl.handle.net/10356/143144
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