Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups
Purpose To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between nonhabitual and habitual groups due to caffeine intake. Method This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years o...
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sg-ntu-dr.10356-1431442020-08-05T05:51:23Z Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups Aishah Ismail Bhatti, Mehwish S. Faye, Ibrahima Lu, Cheng Kai Laude, Augustinus Tang, Tong Boon Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Pulse Waveform Laser Speckle Flowgraphy Purpose To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between nonhabitual and habitual groups due to caffeine intake. Method This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the nonhabitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion The experiment results demonstrated caffeine does modulate OBF significantly and response differently in nonhabitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups. 2020-08-05T05:51:23Z 2020-08-05T05:51:23Z 2018 Journal Article Aishah Ismail, Bhatti, M. S., Faye, I., Lu, C. K., Laude, A., & Tang, T. B. (2018). Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups. Graefe's Archive for Clinical and Experimental Ophthalmology, 256(9), 1711-1721. doi:10.1007/s00417-018-4030-9 0721-832X https://hdl.handle.net/10356/143144 10.1007/s00417-018-4030-9 29876732 2-s2.0-85048041837 9 256 1711 1721 en Graefe's archive for clinical and experimental ophthalmology © 2018 Springer-Verlag GmbH Germany, part of Springer Nature. All rights reserved. |
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Science::Medicine Pulse Waveform Laser Speckle Flowgraphy Aishah Ismail Bhatti, Mehwish S. Faye, Ibrahima Lu, Cheng Kai Laude, Augustinus Tang, Tong Boon Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups |
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Purpose To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between nonhabitual and habitual groups due to caffeine intake. Method This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall,
each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the nonhabitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion The experiment results demonstrated caffeine does modulate OBF significantly and response differently in nonhabitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Aishah Ismail Bhatti, Mehwish S. Faye, Ibrahima Lu, Cheng Kai Laude, Augustinus Tang, Tong Boon |
format |
Article |
author |
Aishah Ismail Bhatti, Mehwish S. Faye, Ibrahima Lu, Cheng Kai Laude, Augustinus Tang, Tong Boon |
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Aishah Ismail |
title |
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups |
title_short |
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups |
title_full |
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups |
title_fullStr |
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups |
title_full_unstemmed |
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups |
title_sort |
pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups |
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2020 |
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https://hdl.handle.net/10356/143144 |
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1681057788012265472 |