The mammalian crumbs complex defines a distinct polarity domain apical of epithelial tight junctions

• Main Authors: Tan, Benedict, Siti Maryam J. M. Yatim, Peng, Suat, Gunaratne, Jayantha, Hunziker, Walter, Ludwig, Alexander
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Par3; Pals1
• Online Access: https://hdl.handle.net/10356/143166; https://doi.org/10.21979/N9/TFWJFO
• Institution: Nanyang Technological University

Epithelial apico-basal polarity is established through the asymmetric cortical distribution of the Par, Crumbs and Scribble polarity modules. Apical (Par and Crumbs) and basolateral (Scribble) polarity modules overlap at the apical-lateral border, which, in mammals, is defined by the apical junction...