Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum

Vertically-aligned mesoporous silica-nanochannel film (VMSF) has been demonstrated as effective anti-fouling and anti-inference layer for constructing electrochemical sensors. Conductive substrate with high electroactivity and adhesion is very important for improving the performance of VMSF based se...

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Main Authors: Xi, Fengna, Xuan, Lingli, Lu, Lili, Huang, Jie, Yan, Fei, Liu, Jiyang, Dong, Xiaoping, Chen, Peng
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/143201
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1432012023-12-29T06:47:41Z Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum Xi, Fengna Xuan, Lingli Lu, Lili Huang, Jie Yan, Fei Liu, Jiyang Dong, Xiaoping Chen, Peng School of Chemical and Biomedical Engineering Engineering::Chemical engineering Mesoporous Silica-nanochannel Reduced Graphene Oxide Vertically-aligned mesoporous silica-nanochannel film (VMSF) has been demonstrated as effective anti-fouling and anti-inference layer for constructing electrochemical sensors. Conductive substrate with high electroactivity and adhesion is very important for improving the performance of VMSF based sensors in terms of stability, sensitivity and discrimination ability. We herein use reduced graphene oxide (rGO) sheets as conductive adhesive and electroactive layer between VMSF and glassy carbon electrode (GCE). VMSF can be stably grown on rGO layer by electrochemically assisted self-assembly method (EASA). Owing to the electroactive properties of rGO, VMSF/rGO/GCE is able to parallel or simultaneously detect small drugs or biomarkers with high sensitivity and distinct oxidation potential for different electroactive organic molecules. Combining the anti-fouling and anti-inference ability of VMSF, direct analysis of small drugs or biomarkers in complex biological (serum) sample is demonstrated. Ministry of Education (MOE) Accepted version We acknowledge the financial support from the Ministry of Education of Singapore (AcRF Tier 2 grant MOE2017-T2-2-005), the financial support from the National Natural Science Foundation of China (No. 21305127), the Zhejiang Provincial Natural Science Foundation of China (Nos. LY19B050008 and LY17B050007). 2020-08-12T05:04:47Z 2020-08-12T05:04:47Z 2019 Journal Article Xi, F., Xuan, L., Lu, L., Huang, J., Yan, F., Liu, J., ... Chen, P. (2019). Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum. Sensors and Actuators B: Chemical, 288, 133-140. doi:10.1016/j.snb.2019.02.115 0925-4005 https://hdl.handle.net/10356/143201 10.1016/j.snb.2019.02.115 2-s2.0-85062206813 288 133 140 en MOE2017-T2-2-005 Sensors and Actuators B: Chemical © 2019 Elsevier B.V. All rights reserved. This paper was published in Sensors and Actuators B: Chemical and is made available with permission of Elsevier B.V. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Chemical engineering
Mesoporous Silica-nanochannel
Reduced Graphene Oxide
spellingShingle Engineering::Chemical engineering
Mesoporous Silica-nanochannel
Reduced Graphene Oxide
Xi, Fengna
Xuan, Lingli
Lu, Lili
Huang, Jie
Yan, Fei
Liu, Jiyang
Dong, Xiaoping
Chen, Peng
Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
description Vertically-aligned mesoporous silica-nanochannel film (VMSF) has been demonstrated as effective anti-fouling and anti-inference layer for constructing electrochemical sensors. Conductive substrate with high electroactivity and adhesion is very important for improving the performance of VMSF based sensors in terms of stability, sensitivity and discrimination ability. We herein use reduced graphene oxide (rGO) sheets as conductive adhesive and electroactive layer between VMSF and glassy carbon electrode (GCE). VMSF can be stably grown on rGO layer by electrochemically assisted self-assembly method (EASA). Owing to the electroactive properties of rGO, VMSF/rGO/GCE is able to parallel or simultaneously detect small drugs or biomarkers with high sensitivity and distinct oxidation potential for different electroactive organic molecules. Combining the anti-fouling and anti-inference ability of VMSF, direct analysis of small drugs or biomarkers in complex biological (serum) sample is demonstrated.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Xi, Fengna
Xuan, Lingli
Lu, Lili
Huang, Jie
Yan, Fei
Liu, Jiyang
Dong, Xiaoping
Chen, Peng
format Article
author Xi, Fengna
Xuan, Lingli
Lu, Lili
Huang, Jie
Yan, Fei
Liu, Jiyang
Dong, Xiaoping
Chen, Peng
author_sort Xi, Fengna
title Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
title_short Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
title_full Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
title_fullStr Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
title_full_unstemmed Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
title_sort improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
publishDate 2020
url https://hdl.handle.net/10356/143201
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