Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum
Vertically-aligned mesoporous silica-nanochannel film (VMSF) has been demonstrated as effective anti-fouling and anti-inference layer for constructing electrochemical sensors. Conductive substrate with high electroactivity and adhesion is very important for improving the performance of VMSF based se...
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sg-ntu-dr.10356-1432012023-12-29T06:47:41Z Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum Xi, Fengna Xuan, Lingli Lu, Lili Huang, Jie Yan, Fei Liu, Jiyang Dong, Xiaoping Chen, Peng School of Chemical and Biomedical Engineering Engineering::Chemical engineering Mesoporous Silica-nanochannel Reduced Graphene Oxide Vertically-aligned mesoporous silica-nanochannel film (VMSF) has been demonstrated as effective anti-fouling and anti-inference layer for constructing electrochemical sensors. Conductive substrate with high electroactivity and adhesion is very important for improving the performance of VMSF based sensors in terms of stability, sensitivity and discrimination ability. We herein use reduced graphene oxide (rGO) sheets as conductive adhesive and electroactive layer between VMSF and glassy carbon electrode (GCE). VMSF can be stably grown on rGO layer by electrochemically assisted self-assembly method (EASA). Owing to the electroactive properties of rGO, VMSF/rGO/GCE is able to parallel or simultaneously detect small drugs or biomarkers with high sensitivity and distinct oxidation potential for different electroactive organic molecules. Combining the anti-fouling and anti-inference ability of VMSF, direct analysis of small drugs or biomarkers in complex biological (serum) sample is demonstrated. Ministry of Education (MOE) Accepted version We acknowledge the financial support from the Ministry of Education of Singapore (AcRF Tier 2 grant MOE2017-T2-2-005), the financial support from the National Natural Science Foundation of China (No. 21305127), the Zhejiang Provincial Natural Science Foundation of China (Nos. LY19B050008 and LY17B050007). 2020-08-12T05:04:47Z 2020-08-12T05:04:47Z 2019 Journal Article Xi, F., Xuan, L., Lu, L., Huang, J., Yan, F., Liu, J., ... Chen, P. (2019). Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum. Sensors and Actuators B: Chemical, 288, 133-140. doi:10.1016/j.snb.2019.02.115 0925-4005 https://hdl.handle.net/10356/143201 10.1016/j.snb.2019.02.115 2-s2.0-85062206813 288 133 140 en MOE2017-T2-2-005 Sensors and Actuators B: Chemical © 2019 Elsevier B.V. All rights reserved. This paper was published in Sensors and Actuators B: Chemical and is made available with permission of Elsevier B.V. application/pdf |
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Engineering::Chemical engineering Mesoporous Silica-nanochannel Reduced Graphene Oxide Xi, Fengna Xuan, Lingli Lu, Lili Huang, Jie Yan, Fei Liu, Jiyang Dong, Xiaoping Chen, Peng Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum |
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Vertically-aligned mesoporous silica-nanochannel film (VMSF) has been demonstrated as effective anti-fouling and anti-inference layer for constructing electrochemical sensors. Conductive substrate with high electroactivity and adhesion is very important for improving the performance of VMSF based sensors in terms of stability, sensitivity and discrimination ability. We herein use reduced graphene oxide (rGO) sheets as conductive adhesive and electroactive layer between VMSF and glassy carbon electrode (GCE). VMSF can be stably grown on rGO layer by electrochemically assisted self-assembly method (EASA). Owing to the electroactive properties of rGO, VMSF/rGO/GCE is able to parallel or simultaneously detect small drugs or biomarkers with high sensitivity and distinct oxidation potential for different electroactive organic molecules. Combining the anti-fouling and anti-inference ability of VMSF, direct analysis of small drugs or biomarkers in complex biological (serum) sample is demonstrated. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Xi, Fengna Xuan, Lingli Lu, Lili Huang, Jie Yan, Fei Liu, Jiyang Dong, Xiaoping Chen, Peng |
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Article |
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Xi, Fengna Xuan, Lingli Lu, Lili Huang, Jie Yan, Fei Liu, Jiyang Dong, Xiaoping Chen, Peng |
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Xi, Fengna |
title |
Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum |
title_short |
Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum |
title_full |
Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum |
title_fullStr |
Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum |
title_full_unstemmed |
Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum |
title_sort |
improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum |
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2020 |
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https://hdl.handle.net/10356/143201 |
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1787136522667950080 |