Delineation of critical amino acids in activation function 1 of progesterone receptor for recruitment of transcription coregulators

• Main Authors: Woo, Amanda Rui En, Sze, Siu Kwan, Chung, Hwa Hwa, Lin, Valerie Chun Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Positively Charged Residues; Progesterone Receptor
• Online Access: https://hdl.handle.net/10356/143287
• Institution: Nanyang Technological University

The activation functions AF1 and AF2 of nuclear receptors mediate the recruitment of coregulators in gene regulation. AF1 is mapped to the highly variable and intrinsically unstructured N terminal domain and AF2 lies in the conserved ligand binding domain. The unstructured nature of AF1 offers struc...