Delineation of critical amino acids in activation function 1 of progesterone receptor for recruitment of transcription coregulators

• المؤلفون الرئيسيون: Woo, Amanda Rui En, Sze, Siu Kwan, Chung, Hwa Hwa, Lin, Valerie Chun Ling
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Positively Charged Residues; Progesterone Receptor
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/143287

The activation functions AF1 and AF2 of nuclear receptors mediate the recruitment of coregulators in gene regulation. AF1 is mapped to the highly variable and intrinsically unstructured N terminal domain and AF2 lies in the conserved ligand binding domain. The unstructured nature of AF1 offers struc...